SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis.
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| Title: | SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis. |
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| Authors: | Njouendou AJ; Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, South West Region, Cameroon.; Phytopharmacy and Drug Discovery Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon., Szarvas T; Department of Urology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122, Essen, Germany.; Department of Urology, Semmelweis University, 1082, Budapest, Hungary., Tiofack AAZ; Molecular Parasitology and Entomology Unit (MPEU), Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, West Region, Cameroon.; Early Detection and Biomarker Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon., Kenfack RN; Early Detection and Biomarker Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon.; Research Unit of Microbiology and Antimicrobial Substances (RUMAS), Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, West Region, Cameroon., Tonouo PD; Early Detection and Biomarker Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon.; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Littoral Region, Cameroon.; Department of Medical Oncology, Douala General Hospital, Douala, Littoral Region, Cameroon., Ananga SN; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Littoral Region, Cameroon.; Department of Medical Oncology, Douala General Hospital, Douala, Littoral Region, Cameroon.; Epidemiology and Clinical Trial Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon., Bell EHMD; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Littoral Region, Cameroon.; Department of Medical Oncology, Douala General Hospital, Douala, Littoral Region, Cameroon.; Epidemiology and Clinical Trial Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon., Simo G; Molecular Parasitology and Entomology Unit (MPEU), Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, West Region, Cameroon.; Directorate of Scientific Affairs, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon., Hoheisel JD; Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Siveke JT; Bridge Institute for Experimental Cancer Therapy, West German Cancer Center, University Hospital Essen, Hufeland Str. 55, 45147, Essen, Germany.; Division for Solid Tumor Translational Oncology German Cancer Research Center (DKFZ)West German Cancer Center, The German Consortium for Translational Cancer Research (DKTK), Essen/Düsseldorf Partner, Site University Hospital Essen, Essen, Germany., Lueong SS; Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, South West Region, Cameroon. smiths-sengkwawoh.lueong@uk-essen.de.; Molecular Parasitology and Entomology Unit (MPEU), Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, West Region, Cameroon. smiths-sengkwawoh.lueong@uk-essen.de.; Early Detection and Biomarker Section, The Cameroon Consortium for Translational Cancer Research (CCOTCARE), Douala, Cameroon. smiths-sengkwawoh.lueong@uk-essen.de.; Bridge Institute for Experimental Cancer Therapy, West German Cancer Center, University Hospital Essen, Hufeland Str. 55, 45147, Essen, Germany. smiths-sengkwawoh.lueong@uk-essen.de.; Division for Solid Tumor Translational Oncology German Cancer Research Center (DKFZ)West German Cancer Center, The German Consortium for Translational Cancer Research (DKTK), Essen/Düsseldorf Partner, Site University Hospital Essen, Essen, Germany. smiths-sengkwawoh.lueong@uk-essen.de. |
| Source: | Molecular cancer [Mol Cancer] 2023 Mar 17; Vol. 22 (1), pp. 52. Date of Electronic Publication: 2023 Mar 17. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1476-4598 |
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| DOI: | 10.1186/s12943-023-01734-w |
