Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.

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Title: Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
Authors: McNamara B; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Harold J; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Manavella D; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Bellone S; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Mutlu L; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Hartwich TMP; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Zipponi M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Yang-Hartwich Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Demirkiran C; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Verzosa MSZ; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Yang K; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Choi J; Department of Biomedical Sciences, Korea University College of Medicine, 02841 Seoul, Republic of Korea., Dong W; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, United States of America., Buza N; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, United States of America., Hui P; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, United States of America., Altwerger G; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Huang GS; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Andikyan V; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Clark M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Ratner E; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Azodi M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Schwartz PE; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America., Burton EA; Plexxikon Inc., South San Francisco, CA 94080, United States of America., Inagaki H; Plexxikon Inc., South San Francisco, CA 94080, United States of America., Albers A; Plexxikon Inc., South San Francisco, CA 94080, United States of America., Zhang C; Plexxikon Inc., South San Francisco, CA 94080, United States of America., Bollag G; Plexxikon Inc., South San Francisco, CA 94080, United States of America., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, CT 06520, United States of America., Santin AD; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, CT 06520, United States of America. Electronic address: alessandro.santin@yale.edu.
Source: Gynecologic oncology [Gynecol Oncol] 2023 May; Vol. 172, pp. 65-71. Date of Electronic Publication: 2023 Mar 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1095-6859
DOI:10.1016/j.ygyno.2023.03.009