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Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.

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Title: Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.
Authors: Germon ZP; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Sillar JR; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia., Mannan A; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Duchatel RJ; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Staudt D; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Murray HC; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Findlay IJ; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Jackson ER; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., McEwen HP; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Douglas AM; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., McLachlan T; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Schjenken JE; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia., Skerrett-Byrne DA; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia., Huang H; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark., Melo-Braga MN; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark.; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Plank MW; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; GlaxoSmithKline, Abbotsford, Victoria, Australia., Alvaro F; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; John Hunter Children's Hospital, New Lambton Heights, NSW, Australia., Chamberlain J; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; John Hunter Children's Hospital, New Lambton Heights, NSW, Australia., De Iuliis G; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia., Aitken RJ; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia., Nixon B; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia., Wei AH; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia., Enjeti AK; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia.; NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia., Huang Y; Children's Cancer Institute, Lowy Cancer Centre, School of Women's and Children's Health, University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia., Lock RB; Children's Cancer Institute, Lowy Cancer Centre, School of Women's and Children's Health, University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia., Larsen MR; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark., Lee H; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Vaghjiani V; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Cain JE; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., de Bock CE; Children's Cancer Institute, Lowy Cancer Centre, School of Women's and Children's Health, University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia., Verrills NM; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Dun MD; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Source: Science signaling [Sci Signal] 2023 Mar 28; Vol. 16 (778), pp. eabp9586. Date of Electronic Publication: 2023 Mar 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.
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  Data: <searchLink fieldCode="AU" term="%22Germon+ZP%22">Germon ZP</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sillar+JR%22">Sillar JR</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mannan+A%22">Mannan A</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Duchatel+RJ%22">Duchatel RJ</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Staudt+D%22">Staudt D</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Murray+HC%22">Murray HC</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; 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Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Douglas+AM%22">Douglas AM</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22McLachlan+T%22">McLachlan T</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Schjenken+JE%22">Schjenken JE</searchLink>; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Skerrett-Byrne+DA%22">Skerrett-Byrne DA</searchLink>; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Melo-Braga+MN%22">Melo-Braga MN</searchLink>; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark.; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Plank+MW%22">Plank MW</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; GlaxoSmithKline, Abbotsford, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Alvaro+F%22">Alvaro F</searchLink>; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; John Hunter Children's Hospital, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Chamberlain+J%22">Chamberlain J</searchLink>; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; John Hunter Children's Hospital, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22De+Iuliis+G%22">De Iuliis G</searchLink>; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Aitken+RJ%22">Aitken RJ</searchLink>; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Nixon+B%22">Nixon B</searchLink>; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+AH%22">Wei AH</searchLink>; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Enjeti+AK%22">Enjeti AK</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia.; NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Children's Cancer Institute, Lowy Cancer Centre, School of Women's and Children's Health, University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Centre, School of Women's and Children's Health, University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Larsen+MR%22">Larsen MR</searchLink>; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Vaghjiani+V%22">Vaghjiani V</searchLink>; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cain+JE%22">Cain JE</searchLink>; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22de+Bock+CE%22">de Bock CE</searchLink>; Children's Cancer Institute, Lowy Cancer Centre, School of Women's and Children's Health, University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Verrills+NM%22">Verrills NM</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dun+MD%22">Dun MD</searchLink>; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
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