The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models.

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Title: The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models.
Authors: Rozowsky J; Section on Biomedical Informatics and Data Science, Yale University, New Haven, CT, USA; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Gao J; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Borsari B; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain., Yang YT; Institute of Science and Technology for Brain-Inspired Intelligence; MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence; MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Galeev T; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Gürsoy G; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Epstein CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Xiong K; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Xu J; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Li T; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Liu J; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Yu K; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Berthel A; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Chen Z; Department of Statistics and Data Science, Yale University, New Haven, CT, USA., Navarro F; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Sun MS; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Wright J; Institute of Cancer Research, London, UK., Chang J; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Cameron CJF; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Shoresh N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gaskell E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Drenkow J; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Adrian J; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Aganezov S; Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Balderrama-Gutierrez G; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA., Banskota S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Corona GB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chee S; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA., Chhetri SB; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Cortez Martins GC; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Danyko C; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Davis CA; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Farid D; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Farrell NP; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gabdank I; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Gofin Y; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Gorkin DU; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA., Gu M; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Hecht V; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hitz BC; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Issner R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jiang Y; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Kirsche M; Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA., Kong X; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Lam BR; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Li S; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Li B; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Li X; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Lin KZ; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Luo R; Department of Computer Science, The University of Hong Kong, Hong Kong, CHN., Mackiewicz M; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Meng R; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Moore JE; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Mudge J; European Bioinformatics Institute, Cambridge, Cambridgeshire, GB., Nelson N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nusbaum C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Popov I; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Pratt HE; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Qiu Y; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA., Ramakrishnan S; Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA., Raymond J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Salichos L; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA; Department of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, NY, USA., Scavelli A; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Schreiber JM; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Sedlazeck FJ; Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., See LH; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Sherman RM; Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA., Shi X; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Shi M; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Sloan CA; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Strattan JS; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Tan Z; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Tanaka FY; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Vlasova A; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain; Comparative Genomics Group, Life Science Programme, Barcelona Supercomputing Centre, Barcelona, Spain; Institute of Research in Biomedicine, Barcelona, Spain., Wang J; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Werner J; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Williams B; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Xu M; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Yan C; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Yu L; Institute of Cancer Research, London, UK., Zaleski C; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Zhang J; Department of Computer Science, University of California, Irvine, Irvine, CA, USA., Ardlie K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cherry JM; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Mendenhall EM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Noble WS; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Weng Z; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Levine ME; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Dobin A; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Wold B; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Mortazavi A; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA., Ren B; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA., Gillis J; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Department of Physiology, University of Toronto, Toronto, ON, Canada., Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Snyder MP; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA., Choudhary J; Institute of Cancer Research, London, UK., Milosavljevic A; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Schatz MC; Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. Electronic address: mschatz@cs.jhu.edu., Bernstein BE; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: Bradley_Bernstein@dfci.harvard.edu., Guigó R; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain; Universitat Pompeu Fabra, Barcelona, Catalonia, Spain. Electronic address: roderic.guigo@crg.eu., Gingeras TR; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. Electronic address: gingeras@cshl.edu., Gerstein M; Section on Biomedical Informatics and Data Science, Yale University, New Haven, CT, USA; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA; Department of Statistics and Data Science, Yale University, New Haven, CT, USA; Department of Computer Science, Yale University, New Haven, CT, USA. Electronic address: mark@gersteinlab.org.
Source: Cell [Cell] 2023 Mar 30; Vol. 186 (7), pp. 1493-1511.e40.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2023.02.018