ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

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Bibliographic Details
Title:	ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.
Authors:	Balmanno K; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Byrne DP; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K., Sale MJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Nassman N; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Eyers PA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
Source:	The Biochemical journal [Biochem J] 2023 May 15; Vol. 480 (9), pp. 587-605.
Publication Type:	Journal Article; Research Support, Non-U.S. Gov't
Journal Info:	Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	1470-8728
DOI:	10.1042/BCJ20220598