Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.

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Bibliographic Details
Title: Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.
Authors: Patel SS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Yu F; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., DeJulius CR; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Fletcher RB; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cherry FK; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lo JH; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Division of Hematology/Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Bezold MG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., d'Arcy R; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Brasuell JE; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cook RS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address: craig.duvall@vanderbilt.edu.
Source: Biomaterials [Biomaterials] 2023 Jun; Vol. 297, pp. 122098. Date of Electronic Publication: 2023 Mar 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-5905
DOI:10.1016/j.biomaterials.2023.122098