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Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.

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Title: Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.
Authors: Patel SS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Yu F; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., DeJulius CR; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Fletcher RB; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cherry FK; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lo JH; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Division of Hematology/Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Bezold MG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., d'Arcy R; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Brasuell JE; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Cook RS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address: craig.duvall@vanderbilt.edu.
Source: Biomaterials [Biomaterials] 2023 Jun; Vol. 297, pp. 122098. Date of Electronic Publication: 2023 Mar 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.
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  Data: <searchLink fieldCode="AU" term="%22Patel+SS%22">Patel SS</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hoogenboezem+EN%22">Hoogenboezem EN</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yu+F%22">Yu F</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22DeJulius+CR%22">DeJulius CR</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Fletcher+RB%22">Fletcher RB</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sorets+AG%22">Sorets AG</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cherry+FK%22">Cherry FK</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lo+JH%22">Lo JH</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Division of Hematology/Oncology, Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bezold+MG%22">Bezold MG</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Francini+N%22">Francini N</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22d'Arcy+R%22">d'Arcy R</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Brasuell+JE%22">Brasuell JE</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cook+RS%22">Cook RS</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Duvall+CL%22">Duvall CL</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address: craig.duvall@vanderbilt.edu.
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  Data: <searchLink fieldCode="JN" term="%228100316%22">Biomaterials</searchLink> [Biomaterials] 2023 Jun; Vol. 297, pp. 122098. <i>Date of Electronic Publication: </i>2023 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8100316 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-5905 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201429612%22">01429612 </searchLink><i>NLM ISO Abbreviation: </i>Biomaterials <i>Subsets: </i>MEDLINE
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              Text: 2023 Jun
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