Model-informed approach to support pediatric dosing for the pan-PI3K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors.
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| Title: | Model-informed approach to support pediatric dosing for the pan-PI3K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors. |
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| Authors: | Morcos PN; Bayer HealthCare Pharmaceuticals, Inc., Whippany, New Jersey, USA., Schlender J; Pharmacometrics/Modeling & Simulation, Pharmaceuticals Division, Bayer AG, Wuppertal, Germany., Burghaus R; Pharmacometrics/Modeling & Simulation, Pharmaceuticals Division, Bayer AG, Wuppertal, Germany., Moss J; BAST Inc. Limited, Leicester, UK., Lloyd A; BAST Inc. Limited, Leicester, UK., Childs BH; Bayer HealthCare Pharmaceuticals, Inc., Whippany, New Jersey, USA., Macy ME; Department of Pediatrics, University of Colorado and Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA., Reid JM; Department of Pharmacology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, USA., Chung J; Bayer HealthCare Pharmaceuticals, Inc., Whippany, New Jersey, USA., Garmann D; Pharmacometrics/Modeling & Simulation, Pharmaceuticals Division, Bayer AG, Wuppertal, Germany. |
| Source: | Clinical and translational science [Clin Transl Sci] 2023 Jul; Vol. 16 (7), pp. 1197-1209. Date of Electronic Publication: 2023 Apr 18. |
| Publication Type: | Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1752-8062 |
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| DOI: | 10.1111/cts.13523 |
