Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.

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Title: Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Authors: Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Gopakumar J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Burugula BB; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Uddin MM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Jahn N; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Belk JA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Bouzid H; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Daniel B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Miao Z; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Ly N; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Mack TM; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA., Luna SE; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Prothro KP; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Mitchell SR; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA, USA.; University of Washington, Seattle, WA, USA., Broome JG; Department of Biostatistics, University of Washington, Seattle, WA, USA.; University of Washington, Seattle, WA, USA.; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA., Taylor KD; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Institute for Translational Genomics and Populations Sciences, Lundquist Institute, Torrance, CA, USA., Guo X; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Lundquist Institute, Torrance, CA, USA., Sinner MF; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany., von Falkenhausen AS; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany., Kääb S; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany., Shuldiner AR; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., O'Connell JR; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., Lewis JP; Department of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.; University of Maryland, Baltimore, MD, USA., Boerwinkle E; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; University of Texas Health at Houston, Houston, TX, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Chami N; The Charles Bronfman Institute of Personalized Medicine, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kenny EE; Institute for Genomic Health, New York, NY, USA.; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute of Personalized Medicine, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fornage M; University of Texas Health at Houston, Houston, TX, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Hou L; Department of Preventive Medicine, Northeastern University, Chicago, IL, USA., Lloyd-Jones DM; Department of Preventive Medicine, Northeastern University, Chicago, IL, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cade BE; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., Psaty BM; University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brody JA; University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Silverman EK; Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Yun JH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Qiao D; Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest Baptist Health, Winston-Salem, NC, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest Baptist Health, Winston-Salem, NC, USA., Cho MH; Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., DeMeo DL; Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Vasan RS; National Heart Lung and Blood Institute's, Boston University's Framingham Heart Study, Framingham, MA, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Johns Hopkins University, Baltimore, MD, USA., Becker LC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Johns Hopkins University, Baltimore, MD, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; University of Michigan, Ann Arbor, MI, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; University of Michigan, Ann Arbor, MI, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University, New Orleans, LA, USA., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Albert Einstein College of Medicine, New York, NY, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA.; Broad Institute, Cambridge, MA, USA., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, USA.; University of Kentucky, Lexington, KY, USA., Irvin MR; University of Alabama at Birmingham, Birmingham, AL, USA., Tiwari H; Department of Biostatistics, University of Alabama, Birmingham, AL, USA., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA., Knight S; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA., Muhlestein JB; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA., Correa A; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Population Health Science, University of Mississippi, Jackson, MS, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gao Y; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; University of Mississippi, Jackson, MS, USA., de Andrade M; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, Lundquist Institute, Torrance, CA, USA., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; University of Virginia, Charlottesville, VA, USA., Tracy RP; Department of Pathology and Laboratory Medicine and Biochemistry, Larner College of Medicine at the University of Vermont, Colchester, VT, USA.; Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA., Konkle BA; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Blood Works Northwest, Seattle, WA, USA., Johnsen JM; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Research Institute, Bloodworks Northwest, Seattle, WA, USA., Wheeler MM; Genome Science, University of Washington, Seattle, WA, USA., Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University, Gothenburg, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skane University Hospital, Malmo, Sweden., Nilsson PM; Department of Internal Medicine, Clinical Sciences, Lund University and Skane University Hospital, Malmo, Sweden., Custer BS; Vitalant Research Institute, San Francisco, CA, USA., Duggirala R; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., McGarvey S; Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.; Department of Epidemiology, Brown University, Providence, RI, USA., Williams LK; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.; Henry Ford Health System, Detroit, MI, USA., Xiao S; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Yang M; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Gu CC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.; Washington University in St Louis, St Louis, MO, USA., Chen YI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Lundquist Institute, Torrance, CA, USA., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Taichung Veterans General Hospital Taiwan, Taichung City, Taiwan., Marcus GM; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA., Kane JP; Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA., Pullinger CR; Cardiovascular Research Institute, University of California, San Francisco, USA., Shoemaker MB; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Medicine and Cardiology, Vanderbilt University, Nashville, TN, USA., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.; University of Illinois at Chicago, Chicago, IL, USA., Roden DM; Departments of Medicine, Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Albert C; Department of Cardiology, Cedars-Sinai, Los Angeles, CA, USA.; Cedars-Sinai, Boston, MA, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Zhou Y; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Manson JE; Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Desai P; Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY, USA.; Englander Institute of Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Johnson AD; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Johns Hopkins University, Baltimore, MD, USA., Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Smith AV; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Kang HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Satpathy AT; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Natarajan P; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Kitzman JO; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Reiner AP; Broad Institute, Cambridge, MA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA., Bick AG; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA. alexander.bick@vumc.org., Jaiswal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sjaiswal@stanford.edu.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. sjaiswal@stanford.edu.
Corporate Authors: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Source: Nature [Nature] 2023 Apr; Vol. 616 (7958), pp. 755-763. Date of Electronic Publication: 2023 Apr 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-023-05806-1