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Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.

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Title: Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.
Authors: Badawi WA; Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt., Rashed M; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Nocentini A; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy., Bonardi A; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy., Abd-Alhaseeb MM; Department of Pharmacology and Toxicology, Damanhour University, Damanhour, Buhaira, Egypt., Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Veerakanellore GB; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Majrashi TA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia., Elgendy B; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.; Chemistry Department, Faculty of Science, Benha University, Benha, Egypt., Gratteri P; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy., Supuran CT; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy., Eldehna WM; Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, Egypt., Elagawany M; Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2201407.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.
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  Data: <searchLink fieldCode="AU" term="%22Badawi+WA%22">Badawi WA</searchLink>; Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt.<br /><searchLink fieldCode="AU" term="%22Rashed+M%22">Rashed M</searchLink>; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Nocentini+A%22">Nocentini A</searchLink>; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy.<br /><searchLink fieldCode="AU" term="%22Bonardi+A%22">Bonardi A</searchLink>; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy.<br /><searchLink fieldCode="AU" term="%22Abd-Alhaseeb+MM%22">Abd-Alhaseeb MM</searchLink>; Department of Pharmacology and Toxicology, Damanhour University, Damanhour, Buhaira, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Rashood+ST%22">Al-Rashood ST</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Veerakanellore+GB%22">Veerakanellore GB</searchLink>; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Majrashi+TA%22">Majrashi TA</searchLink>; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elkaeed+EB%22">Elkaeed EB</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elgendy+B%22">Elgendy B</searchLink>; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.; Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.<br /><searchLink fieldCode="AU" term="%22Gratteri+P%22">Gratteri P</searchLink>; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.<br /><searchLink fieldCode="AU" term="%22Supuran+CT%22">Supuran CT</searchLink>; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy.<br /><searchLink fieldCode="AU" term="%22Eldehna+WM%22">Eldehna WM</searchLink>; Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, Egypt.<br /><searchLink fieldCode="AU" term="%22Elagawany+M%22">Elagawany M</searchLink>; Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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