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Oncogenic CDK13 mutations impede nuclear RNA surveillance.

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Title: Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Authors: Insco ML; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Abraham BJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Dubbury SJ; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kaltheuner IH; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany., Dust S; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany., Wu C; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Chen KY; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Liu D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Bellaousov S; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA., Cox AM; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Martin BJE; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Zhang T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA., Ludwig CG; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Fabo T; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Modhurima R; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Esgdaille DE; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA., Henriques T; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Brown KM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA., Geyer M; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany., Adelman K; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Sharp PA; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Young RA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Boutz PL; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.; Center for Biomedical Informatics, University of Rochester, Rochester, NY 14642, USA., Zon LI; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Source: Science (New York, N.Y.) [Science] 2023 Apr 21; Vol. 380 (6642), pp. eabn7625. Date of Electronic Publication: 2023 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Oncogenic CDK13 mutations impede nuclear RNA surveillance.
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Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Kaltheuner+IH%22">Kaltheuner IH</searchLink>; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dust+S%22">Dust S</searchLink>; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chen+KY%22">Chen KY</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bellaousov+S%22">Bellaousov S</searchLink>; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Cox+AM%22">Cox AM</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Martin+BJE%22">Martin BJE</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Ludwig+CG%22">Ludwig CG</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Fabo+T%22">Fabo T</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Modhurima+R%22">Modhurima R</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Esgdaille+DE%22">Esgdaille DE</searchLink>; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Henriques+T%22">Henriques T</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Brown+KM%22">Brown KM</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Chanock+SJ%22">Chanock SJ</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Geyer+M%22">Geyer M</searchLink>; Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Adelman+K%22">Adelman K</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+PA%22">Sharp PA</searchLink>; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Young+RA%22">Young RA</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Boutz+PL%22">Boutz PL</searchLink>; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.; Center for Biomedical Informatics, University of Rochester, Rochester, NY 14642, USA.<br /><searchLink fieldCode="AU" term="%22Zon+LI%22">Zon LI</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
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