3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.
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| Title: | 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma. |
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| Authors: | Okonechnikov K; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Camgöz A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany., Chapman O; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Wani S; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Park DE; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, 92037, USA.; Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA, 92037, USA., Hübner JM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Chakraborty A; Centers for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, USA., Pagadala M; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Bump R; Peptide Biology Labs, Salk Institute for Biological Studies, La Jolla, CA, USA., Chandran S; Peptide Biology Labs, Salk Institute for Biological Studies, La Jolla, CA, USA., Kraft K; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA., Acuna-Hidalgo R; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute for Medical Genetics and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany., Reid D; Arima Genomics, Inc, San Diego, CA, 92121, USA., Sikkink K; Arima Genomics, Inc, San Diego, CA, 92121, USA., Mauermann M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Juarez EF; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Jenseit A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Robinson JT; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Pajtler KW; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Milde T; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Jäger N; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Fiesel P; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; CCU Neuropathology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Morgan L; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Sridhar S; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Coufal NG; Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA, 92037, USA.; Department of Pediatrics, University of California, San Diego, San Diego, CA, 92093, USA., Levy M; Neurosurgery, University of California San Diego - Rady Children's Hospital, San Diego, CA, 92123, USA., Malicki D; Pathology, University of California San Diego - Rady Children's Hospital, San Diego, CA, 92123, USA., Hobbs C; Rady Children's Institute for Genomic Medicine, San Diego, CA, 92123, USA., Kingsmore S; Rady Children's Institute for Genomic Medicine, San Diego, CA, 92123, USA., Nahas S; Rady Children's Institute for Genomic Medicine, San Diego, CA, 92123, USA., Snuderl M; Department of Pathology, NYU Langone Health, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Crawford J; Department of Neurosciences, University of California San Diego - Rady Children's Hospital, San Diego, CA, 92123, USA., Wechsler-Reya RJ; Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA, 92037, USA.; Department of Pediatrics, University of California, San Diego, San Diego, CA, 92093, USA.; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Davidson TB; Division of Hematology-Oncology, Cancer and Blood Disease Institute and Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA., Cotter J; Division of Hematology-Oncology, Cancer and Blood Disease Institute and Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA., Michaiel G; Division of Hematology-Oncology, Cancer and Blood Disease Institute and Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA., Fleischhack G; German Cancer Consortium (DKTK), West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany., Mundlos S; Max Planck Institute for Molecular Genetics, Berlin, Germany., Schmitt A; Arima Genomics, Inc, San Diego, CA, 92121, USA., Carter H; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA., Michealraj KA; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, ONT, Canada., Kumar SA; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, ONT, Canada., Taylor MD; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, ONT, Canada., Rich J; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, 92037, USA.; Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA, 92037, USA.; Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA, 92037, USA., Buchholz F; National Center for Tumor Diseases (NCT): German Cancer Research Center (DKFZ) Heidelberg, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg and German Cancer Consortium (DKTK) Partner Site Dresden, Dresden, Germany., Mesirov JP; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA.; Moores Cancer Center, University of California San Diego (UCSD), La Jolla, CA, USA., Pfister SM; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Ay F; Centers for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Pediatrics, University of California, San Diego, San Diego, CA, 92093, USA., Dixon JR; Peptide Biology Labs, Salk Institute for Biological Studies, La Jolla, CA, USA., Kool M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Chavez L; Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego (UCSD), San Diego, USA. lukaschavez@health.ucsd.edu.; Rady Children's Institute for Genomic Medicine, San Diego, CA, 92123, USA. lukaschavez@health.ucsd.edu.; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. lukaschavez@health.ucsd.edu.; Moores Cancer Center, University of California San Diego (UCSD), La Jolla, CA, USA. lukaschavez@health.ucsd.edu. |
| Source: | Nature communications [Nat Commun] 2023 Apr 21; Vol. 14 (1), pp. 2300. Date of Electronic Publication: 2023 Apr 21. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-38044-0 |
