Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan.

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Title: Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan.
Authors: Phua CZJ; Genome Institute of Singapore, Agency for Science, Technology, and Research (A* STAR), Singapore, Singapore., Zhao X; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA., Turcios-Hernandez L; Department of Biology, Virginia Commonwealth University, Room 126, 1000 West Cary St. , Richmond, VA, 23284, USA., McKernan M; Department of Biology, Virginia Commonwealth University, Room 126, 1000 West Cary St. , Richmond, VA, 23284, USA., Abyadeh M; Department of Biology, Virginia Commonwealth University, Room 126, 1000 West Cary St. , Richmond, VA, 23284, USA., Ma S; Genome Institute of Singapore, Agency for Science, Technology, and Research (A* STAR), Singapore, Singapore., Promislow D; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.; Department of Biology, University of Washington, Seattle, WA, 98195, USA., Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA., Kaya A; Department of Biology, Virginia Commonwealth University, Room 126, 1000 West Cary St. , Richmond, VA, 23284, USA. kayaa@vcu.edu.
Source: GeroScience [Geroscience] 2023 Aug; Vol. 45 (4), pp. 2161-2178. Date of Electronic Publication: 2023 Apr 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2509-2723
DOI:10.1007/s11357-023-00796-4