Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R.
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| Title: | Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH |
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| Authors: | Zhou Y; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States., Mowlazadeh Haghighi S; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States., Sawyer JR; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States., Hruby VJ; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States., Cai M; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2023 May 25; Vol. 66 (10), pp. 6715-6724. Date of Electronic Publication: 2023 May 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1520-4804 |
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| DOI: | 10.1021/acs.jmedchem.2c01794 |
