Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
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| Title: | Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. |
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| Authors: | Xu Z; aTyr Pharma, San Diego, CA 92121, USA., Goel HL; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Burkart C; aTyr Pharma, San Diego, CA 92121, USA., Burman L; aTyr Pharma, San Diego, CA 92121, USA., Chong YE; aTyr Pharma, San Diego, CA 92121, USA., Barber AG; aTyr Pharma, San Diego, CA 92121, USA., Geng Y; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China., Zhai L; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China., Wang M; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Kumar A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Menefee A; aTyr Pharma, San Diego, CA 92121, USA., Polizzi C; aTyr Pharma, San Diego, CA 92121, USA., Eide L; aTyr Pharma, San Diego, CA 92121, USA., Rauch K; aTyr Pharma, San Diego, CA 92121, USA., Rahman J; aTyr Pharma, San Diego, CA 92121, USA., Hamel K; aTyr Pharma, San Diego, CA 92121, USA., Fogassy Z; aTyr Pharma, San Diego, CA 92121, USA., Klopp-Savino S; aTyr Pharma, San Diego, CA 92121, USA., Paz S; aTyr Pharma, San Diego, CA 92121, USA., Zhang M; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Cubitt A; aTyr Pharma, San Diego, CA 92121, USA., Nangle LA; aTyr Pharma, San Diego, CA 92121, USA., Mercurio AM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2023 May 03; Vol. 15 (694), pp. eadf1128. Date of Electronic Publication: 2023 May 03. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adf1128 |
