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Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.

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Title: Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Authors: Datta D; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Wassarman K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Racie T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Schmidt K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Sigel R; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Janas MM; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA., Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 May 23; Vol. 59 (42), pp. 6347-6350. Date of Electronic Publication: 2023 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1364-548X
DOI:10.1039/d3cc01143g