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Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.

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Title: Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Authors: Datta D; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Wassarman K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Racie T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Schmidt K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Sigel R; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Janas MM; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com., Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA., Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 May 23; Vol. 59 (42), pp. 6347-6350. Date of Electronic Publication: 2023 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
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  Data: <searchLink fieldCode="AU" term="%22Datta+D%22">Datta D</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Theile+CS%22">Theile CS</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Wassarman+K%22">Wassarman K</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Racie+T%22">Racie T</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Schmidt+K%22">Schmidt K</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Sigel+R%22">Sigel R</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Janas+MM%22">Janas MM</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.<br /><searchLink fieldCode="AU" term="%22Egli+M%22">Egli M</searchLink>; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.<br /><searchLink fieldCode="AU" term="%22Manoharan+M%22">Manoharan M</searchLink>; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. mmanoharan@alnylam.com.
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  Data: <searchLink fieldCode="JN" term="%229610838%22">Chemical communications (Cambridge, England)</searchLink> [Chem Commun (Camb)] 2023 May 23; Vol. 59 (42), pp. 6347-6350. <i>Date of Electronic Publication: </i>2023 May 23.
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              Text: 2023 May 23
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