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Signal peptide mimicry primes Sec61 for client-selective inhibition.

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Title: Signal peptide mimicry primes Sec61 for client-selective inhibition.
Authors: Rehan S; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Tranter D; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Sharp PP; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Craven GB; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Lowe E; Kezar Life Sciences, South San Francisco, CA, USA., Anderl JL; Kezar Life Sciences, South San Francisco, CA, USA., Muchamuel T; Kezar Life Sciences, South San Francisco, CA, USA., Abrishami V; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Kuivanen S; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Wenzell NA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Jennings A; Kezar Life Sciences, South San Francisco, CA, USA., Kalyanaraman C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of California, San Francisco, CA, USA., Strandin T; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Javanainen M; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Vapalahti O; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Jacobson MP; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of California, San Francisco, CA, USA., McMinn D; Kezar Life Sciences, South San Francisco, CA, USA., Kirk CJ; Kezar Life Sciences, South San Francisco, CA, USA., Huiskonen JT; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Taunton J; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. jack.taunton@ucsf.edu., Paavilainen VO; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. ville.paavilainen@helsinki.fi.
Source: Nature chemical biology [Nat Chem Biol] 2023 Sep; Vol. 19 (9), pp. 1054-1062. Date of Electronic Publication: 2023 May 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rehan+S%22">Rehan S</searchLink>; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Tranter+D%22">Tranter D</searchLink>; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sharp+PP%22">Sharp PP</searchLink>; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Craven+GB%22">Craven GB</searchLink>; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lowe+E%22">Lowe E</searchLink>; Kezar Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Anderl+JL%22">Anderl JL</searchLink>; Kezar Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Muchamuel+T%22">Muchamuel T</searchLink>; Kezar Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Abrishami+V%22">Abrishami V</searchLink>; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kuivanen+S%22">Kuivanen S</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wenzell+NA%22">Wenzell NA</searchLink>; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jennings+A%22">Jennings A</searchLink>; Kezar Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kalyanaraman+C%22">Kalyanaraman C</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Strandin+T%22">Strandin T</searchLink>; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Javanainen+M%22">Javanainen M</searchLink>; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Vapalahti+O%22">Vapalahti O</searchLink>; Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Jacobson+MP%22">Jacobson MP</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22McMinn+D%22">McMinn D</searchLink>; Kezar Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kirk+CJ%22">Kirk CJ</searchLink>; Kezar Life Sciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huiskonen+JT%22">Huiskonen JT</searchLink>; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Taunton+J%22">Taunton J</searchLink>; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. jack.taunton@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Paavilainen+VO%22">Paavilainen VO</searchLink>; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. ville.paavilainen@helsinki.fi.
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