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The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.

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Title: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
Authors: Chang Y; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Keramatnia F; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN., Ghate PS; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Nishiguchi G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN., Gao Q; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN., Chepyala D; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN., Mishra A; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN., High AA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN., Goto H; Division of Hemato-Oncology/Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan., Akahane K; Department of Pediatrics, School of Medicine, University of Yamanashi, Chuo, Japan., Peng J; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN., Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN., Fischer M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.; Cancer Biology Program, St. Jude Children's Research Hospital, Memphis, TN., Rankovic Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Cancer Biology Program, St. Jude Children's Research Hospital, Memphis, TN., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN.
Source: Blood [Blood] 2023 Aug 17; Vol. 142 (7), pp. 629-642.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Chang+Y%22">Chang Y</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Keramatnia+F%22">Keramatnia F</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Ghate+PS%22">Ghate PS</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Nishiguchi+G%22">Nishiguchi G</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Iacobucci+I%22">Iacobucci I</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Chepyala+D%22">Chepyala D</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Mishra+A%22">Mishra A</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22High+AA%22">High AA</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Goto+H%22">Goto H</searchLink>; Division of Hemato-Oncology/Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Akahane+K%22">Akahane K</searchLink>; Department of Pediatrics, School of Medicine, University of Yamanashi, Chuo, Japan.<br /><searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Yang+JJ%22">Yang JJ</searchLink>; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Fischer+M%22">Fischer M</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.; Cancer Biology Program, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Rankovic+Z%22">Rankovic Z</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Cancer Biology Program, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Mullighan+CG%22">Mullighan CG</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN.
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        Value: 10.1182/blood.2022017813
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