The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
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| Title: | The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia. |
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| Authors: | Chang Y; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Keramatnia F; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN., Ghate PS; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Nishiguchi G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN., Gao Q; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN., Chepyala D; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN., Mishra A; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN., High AA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN., Goto H; Division of Hemato-Oncology/Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan., Akahane K; Department of Pediatrics, School of Medicine, University of Yamanashi, Chuo, Japan., Peng J; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN., Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN., Fischer M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN.; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN.; Cancer Biology Program, St. Jude Children's Research Hospital, Memphis, TN., Rankovic Z; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN.; Cancer Biology Program, St. Jude Children's Research Hospital, Memphis, TN., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN. |
| Source: | Blood [Blood] 2023 Aug 17; Vol. 142 (7), pp. 629-642. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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