Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes.
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| Title: | Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes. |
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| Authors: | McAllan L; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Baranasic D; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Villicaña S; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Brown S; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Lehne B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK., Adamo M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Jenkinson A; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Elkalaawy M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Mohammadi B; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Hashemi M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Fernandes N; Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK., Lambie N; Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK., Williams R; Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK., Christiansen C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, UK., Yang Y; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; School of Cardiovascular and Metabolic Medicine and Sciences, James Black Centre, King's College London British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK., Zudina L; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK., Lagou V; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Tan S; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Castillo-Fernandez J; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., King JWD; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Pathology, National University Hospital, Singapore, Singapore., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research Biomedical Research Centre, Imperial College London, London, UK., Scott J; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Prokopenko I; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation., Cebola I; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Loh M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Lenhard B; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Batterham RL; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK.; Centre for Obesity Research, Rayne Institute, Department of Medicine, University College, London, WC1E 6JJ, UK.; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, W1T 7DN, UK., Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Scott WR; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK. w.scott@imperial.ac.uk.; MRC London Institute of Medical Sciences, London, W12 0NN, UK. w.scott@imperial.ac.uk.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK. w.scott@imperial.ac.uk.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK. w.scott@imperial.ac.uk. |
| Source: | Nature communications [Nat Commun] 2023 May 15; Vol. 14 (1), pp. 2784. Date of Electronic Publication: 2023 May 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-38439-z |
