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Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.

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Title: Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.
Authors: Moles E; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Australian Centre for Nanomedicine, Faculty of Engineering, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Howard CB; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia., Huda P; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia., Karsa M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., McCalmont H; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Kimpton K; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Duly A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Chen Y; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Huang Y; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Tursky ML; Department of Haematology and Bone Marrow Transplant, St Vincent's Hospital Sydney, Sydney 2010, Australia.; St Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, Australia.; St Vincent Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Ma D; Department of Haematology and Bone Marrow Transplant, St Vincent's Hospital Sydney, Sydney 2010, Australia.; St Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, Australia.; St Vincent Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Bustamante S; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney 2052, Australia., Pickford R; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney 2052, Australia., Connerty P; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Omari S; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Jolly CJ; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia., Joshi S; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia., Shen S; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia., Pimanda JE; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Department of Haematology, Prince of Wales Hospital, Sydney 2031, Australia., Dolnikov A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Cheung LC; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, Western Australia 6009, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia 6102, Australia., Kotecha RS; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, Western Australia 6009, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia 6102, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia 6009, Australia.; School of Medicine, University of Western Australia, Perth, Western Australia 6009, Australia., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.; University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Sydney 2052, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., de Bock CE; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Somers K; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Thurecht KJ; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia.; Centre for Advanced Imaging, ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, St Lucia 4072, Australia., Kavallaris M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Australian Centre for Nanomedicine, Faculty of Engineering, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.
Source: Science translational medicine [Sci Transl Med] 2023 May 17; Vol. 15 (696), pp. eabm1262. Date of Electronic Publication: 2023 May 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.abm1262