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Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer.

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Title: Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer.
Authors: Waryah C; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia., Cursons J; Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia., Foroutan M; Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia., Pflueger C; Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Perth, WA, 6009, Australia.; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, 6 Verdun St, Perth, WA, 6009, Australia., Wang E; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia., Molania R; Population Health and Immunity Division, Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, 3010, Australia., Woodward E; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia., Sorolla A; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia., Wallis C; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia., Moses C; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Evolutionary Neurogenomics, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, XH 1098, The Netherlands., Glas I; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia., Magalhães L; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Postgraduate Program of Genetics and Molecular Biology, Institute of Biological Sciences, Federal University of Pará, Belém, 66075-110, Brazil., Thompson EW; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, 4000, Australia.; Translational Research Institute, Brisbane, QLD, 4102, Australia., Fearnley LG; Population Health and Immunity Division, Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3800, Australia., Chaffer CL; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia.; St Vincent's Clinical School, UNSW Medicine, Darlinghurst, NSW, 2010, Australia., Davis M; Population Health and Immunity Division, Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, 3010, Australia., Papenfuss AT; Population Health and Immunity Division, Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3800, Australia., Redfern A; School of Medicine, University of Western Australia, Perth, WA, 6009, Australia., Lister R; Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Perth, WA, 6009, Australia.; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, 6 Verdun St, Perth, WA, 6009, Australia., Esteller M; Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, 08916, Spain.; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, 28029, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, 08010, Spain.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, 08007, Spain., Blancafort P; Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.; Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Aug; Vol. 10 (22), pp. e2301802. Date of Electronic Publication: 2023 May 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2198-3844
DOI:10.1002/advs.202301802