MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.

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Title: MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.
Authors: Branch MR; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Hsu CL; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA., Ohnishi K; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA., Shen WC; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA., Lee E; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA., Meisenhelder J; Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA., Winborn B; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Sopher BL; Department of Pathology, University of Washington Medical Center, Seattle, WA, USA., Taylor JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Hunter T; Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA., La Spada AR; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA alaspada@uci.edu.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA.; UCI Institute for Neurotherapeutics, University of California, Irvine, CA, USA.
Source: Life science alliance [Life Sci Alliance] 2023 May 23; Vol. 6 (8). Date of Electronic Publication: 2023 May 23 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2575-1077
DOI:10.26508/lsa.202201525