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MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.

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Title: MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.
Authors: Branch MR; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Hsu CL; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA., Ohnishi K; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA., Shen WC; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA., Lee E; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA., Meisenhelder J; Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA., Winborn B; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Sopher BL; Department of Pathology, University of Washington Medical Center, Seattle, WA, USA., Taylor JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Hunter T; Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA., La Spada AR; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA alaspada@uci.edu.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA.; UCI Institute for Neurotherapeutics, University of California, Irvine, CA, USA.
Source: Life science alliance [Life Sci Alliance] 2023 May 23; Vol. 6 (8). Date of Electronic Publication: 2023 May 23 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.
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  Data: <searchLink fieldCode="AU" term="%22Branch+MR%22">Branch MR</searchLink>; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+CL%22">Hsu CL</searchLink>; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ohnishi+K%22">Ohnishi K</searchLink>; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shen+WC%22">Shen WC</searchLink>; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meisenhelder+J%22">Meisenhelder J</searchLink>; Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Winborn+B%22">Winborn B</searchLink>; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sopher+BL%22">Sopher BL</searchLink>; Department of Pathology, University of Washington Medical Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+JP%22">Taylor JP</searchLink>; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hunter+T%22">Hunter T</searchLink>; Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22La+Spada+AR%22">La Spada AR</searchLink>; Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA alaspada@uci.edu.; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.; Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA.; UCI Institute for Neurotherapeutics, University of California, Irvine, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101728869%22">Life science alliance</searchLink> [Life Sci Alliance] 2023 May 23; Vol. 6 (8). <i>Date of Electronic Publication: </i>2023 May 23 (<i>Print Publication: </i>2023).
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  Data: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Life+Science+Alliance%2C+LLC%22">Life Science Alliance, LLC </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101728869 <i>Publication Model: </i>Electronic-Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2575-1077 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225751077%22">25751077 </searchLink><i>NLM ISO Abbreviation: </i>Life Sci Alliance <i>Subsets: </i>MEDLINE
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