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Structural basis of purine nucleotide inhibition of human uncoupling protein 1.

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Title: Structural basis of purine nucleotide inhibition of human uncoupling protein 1.
Authors: Jones SA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK., Gogoi P; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, 10-124 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5158, USA., Ruprecht JJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK., King MS; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK., Lee Y; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK., Zögg T; VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, B-1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium., Pardon E; VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, B-1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium., Chand D; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK., Steimle S; Department of Biochemistry and Biophysics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA., Copeman DM; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK., Cotrim CA; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK., Steyaert J; VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, B-1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium., Crichton PG; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK., Moiseenkova-Bell V; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, 10-124 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5158, USA., Kunji ERS; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.
Source: Science advances [Sci Adv] 2023 Jun 02; Vol. 9 (22), pp. eadh4251. Date of Electronic Publication: 2023 May 31.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Jones+SA%22">Jones SA</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Gogoi+P%22">Gogoi P</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, 10-124 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5158, USA.<br /><searchLink fieldCode="AU" term="%22Ruprecht+JJ%22">Ruprecht JJ</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22King+MS%22">King MS</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Zögg+T%22">Zögg T</searchLink>; VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, B-1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Pardon+E%22">Pardon E</searchLink>; VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, B-1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Chand+D%22">Chand D</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Steimle+S%22">Steimle S</searchLink>; Department of Biochemistry and Biophysics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Copeman+DM%22">Copeman DM</searchLink>; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.<br /><searchLink fieldCode="AU" term="%22Cotrim+CA%22">Cotrim CA</searchLink>; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.<br /><searchLink fieldCode="AU" term="%22Steyaert+J%22">Steyaert J</searchLink>; VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, B-1050 Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Crichton+PG%22">Crichton PG</searchLink>; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.<br /><searchLink fieldCode="AU" term="%22Moiseenkova-Bell+V%22">Moiseenkova-Bell V</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, 10-124 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5158, USA.<br /><searchLink fieldCode="AU" term="%22Kunji+ERS%22">Kunji ERS</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Cambridge CB2 0XY, UK.
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