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An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity.

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Title: An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity.
Authors: Cheng LS; Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001, Anhui, China.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd., Hefei, 230088, Anhui, China., Zhu M; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China., Gao Y; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China., Liu WT; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Yin W; Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001, Anhui, China., Zhou P; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Zhu Z; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China., Niu L; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China., Zeng X; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Zhang D; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Fang Q; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Wang F; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Zhao Q; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China., Zhang Y; School of Health Service Management, Anhui Medical University, Hefei, 230032, Anhui, China. zhangymail@ahmu.edu.cn., Shen G; Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.
Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2023 May 31; Vol. 28 (1), pp. 47. Date of Electronic Publication: 2023 May 31.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
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  Data: An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+LS%22">Cheng LS</searchLink>; Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001, Anhui, China.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd., Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Liu+WT%22">Liu WT</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Yin+W%22">Yin W</searchLink>; Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Niu+L%22">Niu L</searchLink>; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Fang+Q%22">Fang Q</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Hefei HankeMab Biotechnology Limited, Hefei, 230088, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; School of Health Service Management, Anhui Medical University, Hefei, 230032, Anhui, China. zhangymail@ahmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shen+G%22">Shen G</searchLink>; Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229607427%22">Cellular & molecular biology letters</searchLink> [Cell Mol Biol Lett] 2023 May 31; Vol. 28 (1), pp. 47. <i>Date of Electronic Publication: </i>2023 May 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607427 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1689-1392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214258153%22">14258153 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Biol Lett <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1186/s11658-023-00461-w
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        Text: English
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        StartPage: 47
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      – TitleFull: An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity.
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              Text: 2023 May 31
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