Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.

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Title: Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.
Authors: Wu X; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Manske MK; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Ruan GJ; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Witter TL; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Nowakowski KE; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Abeykoon JP; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Tang X; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Yu Y; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Gwin KA; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wu A; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA., Taupin V; Electron Microscopy Core, University of California San Diego, La Jolla, CA, USA., Bhardwaj V; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Paludo J; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Dasari S; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Dong H; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA., Ansell SM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Badley AD; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Schellenberg MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Witzig TE; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Source: IScience [iScience] 2023 Jun 16; Vol. 26 (6), pp. 106929. Date of Electronic Publication: 2023 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2023.106929