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Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.

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Title: Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.
Authors: Wu X; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Manske MK; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Ruan GJ; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Witter TL; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Nowakowski KE; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Abeykoon JP; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Tang X; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Yu Y; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Gwin KA; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wu A; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA., Taupin V; Electron Microscopy Core, University of California San Diego, La Jolla, CA, USA., Bhardwaj V; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Paludo J; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Dasari S; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Dong H; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA., Ansell SM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Badley AD; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Schellenberg MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Witzig TE; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Source: IScience [iScience] 2023 Jun 16; Vol. 26 (6), pp. 106929. Date of Electronic Publication: 2023 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Manske+MK%22">Manske MK</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Ruan+GJ%22">Ruan GJ</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Witter+TL%22">Witter TL</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Nowakowski+KE%22">Nowakowski KE</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Abeykoon+JP%22">Abeykoon JP</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Gwin+KA%22">Gwin KA</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wu+A%22">Wu A</searchLink>; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Taupin+V%22">Taupin V</searchLink>; Electron Microscopy Core, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhardwaj+V%22">Bhardwaj V</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Paludo+J%22">Paludo J</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Dasari+S%22">Dasari S</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Ansell+SM%22">Ansell SM</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Badley+AD%22">Badley AD</searchLink>; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Schellenberg+MJ%22">Schellenberg MJ</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Witzig+TE%22">Witzig TE</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2023 Jun 16; Vol. 26 (6), pp. 106929. <i>Date of Electronic Publication: </i>2023 May 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101724038 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-0042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225890042%22">25890042 </searchLink><i>NLM ISO Abbreviation: </i>iScience <i>Subsets: </i>PubMed not MEDLINE
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