Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
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| Title: | Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. |
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| Authors: | Chen X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Wolfe DA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Bindu DS; Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA., Zhang M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Taskin N; Allen Institute for Brain Science, Seattle, WA, USA., Goertsen D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Shay TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Sullivan EE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Huang SF; Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland., Ravindra Kumar S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Arokiaraj CM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Plattner VM; Sainsbury Wellcome Centre, University College London, London, UK., Campos LJ; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA., Mich JK; Allen Institute for Brain Science, Seattle, WA, USA., Monet D; Allen Institute for Brain Science, Seattle, WA, USA., Ngo V; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA., Ding X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Omstead V; Allen Institute for Brain Science, Seattle, WA, USA., Weed N; Allen Institute for Brain Science, Seattle, WA, USA., Bishaw Y; Allen Institute for Brain Science, Seattle, WA, USA., Gore BB; Allen Institute for Brain Science, Seattle, WA, USA., Lein ES; Allen Institute for Brain Science, Seattle, WA, USA., Akrami A; Sainsbury Wellcome Centre, University College London, London, UK., Miller C; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA., Levi BP; Allen Institute for Brain Science, Seattle, WA, USA., Keller A; Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zürich, Switzerland., Ting JT; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Fox AS; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA., Eroglu C; Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA., Gradinaru V; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. viviana@caltech.edu. |
| Source: | Nature communications [Nat Commun] 2023 Jun 08; Vol. 14 (1), pp. 3345. Date of Electronic Publication: 2023 Jun 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-38582-7 |
