A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration.

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Title: A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration.
Authors: Orozco LD; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA., Owen LA; Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Population Health Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Obstetrics and Gynecology, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Hofmann J; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Stockwell AD; Department of Human Genetics, Genentech, South San Francisco, CA 94080, USA., Tao J; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Haller S; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Mukundan VT; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA., Clarke C; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA., Lund J; Departments of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Sridhar A; Department of Human Pathobiology & OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA., Mayba O; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA., Barr JL; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Zavala RA; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Graves EC; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Zhang C; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Husami N; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Finley R; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Au E; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA., Lillvis JH; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Veterans Administration Western New York Healthcare System, Buffalo, NY 14212, USA., Farkas MH; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Veterans Administration Western New York Healthcare System, Buffalo, NY 14212, USA., Shakoor A; Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA., Sherva R; Department of Medicine, Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118, USA., Kim IK; Retina Service, Massachusetts Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA., Kaminker JS; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA., Townsend MJ; Department of Human Pathobiology & OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA., Farrer LA; Department of Medicine, Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118, USA., Yaspan BL; Department of Human Genetics, Genentech, South San Francisco, CA 94080, USA., Chen HH; Department of Human Pathobiology & OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA., DeAngelis MM; Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Population Health Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Genetics, Genomics and Bioinformatics Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Source: Cell genomics [Cell Genom] 2023 Apr 18; Vol. 3 (6), pp. 100302. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE
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  Data: A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Orozco+LD%22">Orozco LD</searchLink>; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Owen+LA%22">Owen LA</searchLink>; Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Population Health Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Obstetrics and Gynecology, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Hofmann+J%22">Hofmann J</searchLink>; Department of Pathology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Stockwell+AD%22">Stockwell AD</searchLink>; Department of Human Genetics, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Tao+J%22">Tao J</searchLink>; Department of Pathology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Haller+S%22">Haller S</searchLink>; Department of Pathology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Mukundan+VT%22">Mukundan VT</searchLink>; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+C%22">Clarke C</searchLink>; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lund+J%22">Lund J</searchLink>; Departments of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Sridhar+A%22">Sridhar A</searchLink>; Department of Human Pathobiology & OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Mayba+O%22">Mayba O</searchLink>; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Barr+JL%22">Barr JL</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Zavala+RA%22">Zavala RA</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Graves+EC%22">Graves EC</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Husami+N%22">Husami N</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Finley+R%22">Finley R</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Au+E%22">Au E</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.<br /><searchLink fieldCode="AU" term="%22Lillvis+JH%22">Lillvis JH</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Veterans Administration Western New York Healthcare System, Buffalo, NY 14212, USA.<br /><searchLink fieldCode="AU" term="%22Farkas+MH%22">Farkas MH</searchLink>; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Veterans Administration Western New York Healthcare System, Buffalo, NY 14212, USA.<br /><searchLink fieldCode="AU" term="%22Shakoor+A%22">Shakoor A</searchLink>; Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.<br /><searchLink fieldCode="AU" term="%22Sherva+R%22">Sherva R</searchLink>; Department of Medicine, Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Kim+IK%22">Kim IK</searchLink>; Retina Service, Massachusetts Eye & Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Kaminker+JS%22">Kaminker JS</searchLink>; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Townsend+MJ%22">Townsend MJ</searchLink>; Department of Human Pathobiology & OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Farrer+LA%22">Farrer LA</searchLink>; Department of Medicine, Biomedical Genetics, Boston University School of Medicine, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Yaspan+BL%22">Yaspan BL</searchLink>; Department of Human Genetics, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Department of Human Pathobiology & OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22DeAngelis+MM%22">DeAngelis MM</searchLink>; Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Population Health Sciences, University of Utah School of Medicine, The University of Utah, Salt Lake City, UT 84132, USA.; Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.; Genetics, Genomics and Bioinformatics Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
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  Data: <searchLink fieldCode="JN" term="%229918284260106676%22">Cell genomics</searchLink> [Cell Genom] 2023 Apr 18; Vol. 3 (6), pp. 100302. <i>Date of Electronic Publication: </i>2023 Apr 18 (<i>Print Publication: </i>2023).
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