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Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease.

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Title: Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease.
Authors: Phillips B; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Western D; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Wang L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Timsina J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sun Y; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Gorijala P; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Yang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Do A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Nykänen NP; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA., Alvarez I; Memory Disorders Unit, Department of Neurology, University Hospital Mutua Terrassa, Terrassa, Spain., Aguilar M; Memory Disorders Unit, Department of Neurology, University Hospital Mutua Terrassa, Terrassa, Spain., Pastor P; Unit of Neurodegenerative diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain., Morris JC; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Fagan AM; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Puerta R; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center On Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., García-González P; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center On Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., de Rojas I; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center On Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center On Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center On Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Ruiz A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center On Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Perlmutter JS; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Perrin RJ; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA. cruchagac@wustl.edu.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. cruchagac@wustl.edu.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA. cruchagac@wustl.edu.
Corporate Authors: Dominantly Inherited Alzheimer Network (DIAN) Consortia
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2023 Jul 08; Vol. 9 (1), pp. 107. Date of Electronic Publication: 2023 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2373-8057
DOI:10.1038/s41531-023-00555-4