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Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors.

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Title: Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors.
Authors: Matos AI; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular João Lobo Antunes, Lisbon Academic Medical Center, Universidade de Lisboa, Lisbon, 1649-028, Portugal., Peres C; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular João Lobo Antunes, Lisbon Academic Medical Center, Universidade de Lisboa, Lisbon, 1649-028, Portugal., Carreira B; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Moura LIF; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Acúrcio RC; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Vogel T; Department of Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, 01062, Dresden, Germany., Wegener E; Department of Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, 01062, Dresden, Germany., Ribeiro F; Faculdade de Medicina, Instituto de Medicina Molecular João Lobo Antunes, Lisbon Academic Medical Center, Universidade de Lisboa, Lisbon, 1649-028, Portugal., Afonso MB; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Santos FMF; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Martínez-Barriocanal Á; Group of Biomedical Research in Digestive Tract Tumors, CIBBIM-Nanomedicine, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, 08035, Spain.; Group of Molecular Oncology, Lleida Biomedical Research Institute (IRBLleida), Lleida, 25198, Spain., Arango D; Group of Biomedical Research in Digestive Tract Tumors, CIBBIM-Nanomedicine, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, 08035, Spain.; Group of Molecular Oncology, Lleida Biomedical Research Institute (IRBLleida), Lleida, 25198, Spain., Viana AS; Centro de Química Estrutural, Departamento de Química e Bioquímica, Institute of Molecular Sciences, Faculty of Sciences, Universidade de Lisboa, Lisbon, 1749-016, Portugal., Góis PMP; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Silva LC; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Rodrigues CMP; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal., Graca L; Faculdade de Medicina, Instituto de Medicina Molecular João Lobo Antunes, Lisbon Academic Medical Center, Universidade de Lisboa, Lisbon, 1649-028, Portugal., Jordan R; Department of Chemistry, Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, 01062, Dresden, Germany., Satchi-Fainaro R; Department of Physiology and Pharmacology, Faculty of Medicine, Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978, Israel., Florindo HF; Grouf of BioNanoSciences - Drug Delivery and Immunoengineering, Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Sep; Vol. 10 (25), pp. e2300299. Date of Electronic Publication: 2023 Jul 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2198-3844
DOI:10.1002/advs.202300299