Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
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| Title: | Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor. |
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| Authors: | Mugnaini C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Kostrzewa M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy., Casini M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Kumar P; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy., Catallo V; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Allarà M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy., Guastaferro L; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Brizzi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Paolino M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Tafi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Kapatais C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Giorgi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Vacondio F; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy., Mor M; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy., Corelli F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Ligresti A; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy. |
| Source: | Molecules (Basel, Switzerland) [Molecules] 2023 Jun 24; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1420-3049 |
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| DOI: | 10.3390/molecules28134958 |
