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Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.

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Title: Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Authors: Mugnaini C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Kostrzewa M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy., Casini M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Kumar P; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy., Catallo V; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Allarà M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy., Guastaferro L; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Brizzi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Paolino M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Tafi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Kapatais C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Giorgi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Vacondio F; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy., Mor M; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy., Corelli F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy., Ligresti A; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Source: Molecules (Basel, Switzerland) [Molecules] 2023 Jun 24; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2023 Jun 24; Vol. 28 (13). <i>Date of Electronic Publication: </i>2023 Jun 24.
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