Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.

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Title: Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.
Authors: Robertson SJ; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA.; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Bedard O; The Jackson Laboratory, Bar Harbor, ME, USA., McNally KL; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Shaia C; Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Clancy CS; Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Lewis M; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Broeckel RM; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Chiramel AI; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Shannon JG; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Sturdevant GL; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA.; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Rosenke R; Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA., Anzick SL; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Forte E; The Jackson Laboratory, Bar Harbor, ME, USA.; Springer Nature, New York, NY, USA., Preuss C; The Jackson Laboratory, Bar Harbor, ME, USA., Baker CN; The Jackson Laboratory, Bar Harbor, ME, USA., Harder JM; The Jackson Laboratory, Bar Harbor, ME, USA., Brunton C; The Jackson Laboratory, Bar Harbor, ME, USA., Munger S; The Jackson Laboratory, Bar Harbor, ME, USA., Bruno DP; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Lack JB; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Leung JM; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Shamsaddini A; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Gardina P; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Sturdevant DE; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Sun J; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Martens C; Research Technologies Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Holland SM; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Rosenthal NA; The Jackson Laboratory, Bar Harbor, ME, USA. Nadia.Rosenthal@jax.com.; National Heart and Lung Institute, Imperial College London, London, UK. Nadia.Rosenthal@jax.com., Best SM; Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA. sbest@niaid.nih.gov.; Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA. sbest@niaid.nih.gov.
Source: Nature communications [Nat Commun] 2023 Jul 25; Vol. 14 (1), pp. 4481. Date of Electronic Publication: 2023 Jul 25.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-023-40076-5