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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.

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Title: Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Authors: Xie SC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Wang Y; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom., Morton CJ; Biomedical Manufacturing Program, CSIRO, Clayton South, Australia., Metcalfe RD; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Dogovski C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dunn E; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Luth MR; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Kumpornsin K; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Calibr, Division of the Scripps Research Institute, La Jolla, CA 92037, USA., Istvan ES; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, USA., Park JS; Research Institute of Pharmaceutical Sciences & Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Fairhurst KJ; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Ketprasit N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Yildirim O; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bhebhe MN; School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia., Klug DM; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom., Rutledge PJ; School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., De Souza ML; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Siqueira-Neto JL; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Du Y; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Puhalovich T; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Amini M; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Shami G; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Loesbanluechai D; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Nie S; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Williamson N; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Jana GP; TCG Lifesciences Private Limited, Salt-lake Electronics Complex, Kolkata, India., Maity BC; TCG Lifesciences Private Limited, Salt-lake Electronics Complex, Kolkata, India., Thomson P; School of Chemistry, The University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom., Foley T; School of Chemistry, The University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom., Tan DS; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Han BW; Research Institute of Pharmaceutical Sciences & Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, USA., Burrows J; Medicines for Malaria Venture, 20, Route de Pré-Bois 1215, Geneva 15, Switzerland., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 4HN, United Kingdom., Winzeler EA; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Griffin MDW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Todd MH; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom.; Structural Genomics Consortium, University College London, London WC1N 1AX, United Kingdom., Tilley L; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
Source: Research square [Res Sq] 2023 Jul 27. Date of Electronic Publication: 2023 Jul 27.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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