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STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.

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Title: STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.
Authors: Pencik J; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria. jpencik@salk.edu.; Center for Biomarker Research in Medicine, 8010, Graz, Austria. jpencik@salk.edu.; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. jpencik@salk.edu.; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090, Vienna, Austria. jpencik@salk.edu., Philippe C; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090, Vienna, Austria., Schlederer M; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Atas E; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Pecoraro M; Institute for Research in Biomedicine, Università Della Svizzera Italiana, 6500, Bellinzona, Switzerland., Grund-Gröschke S; Department of Biosciences and Medical Biology, Cancer Cluster Salzburg, Paris-Lodron University of Salzburg, 5020, Salzburg, Austria., Li WJ; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.; Experimental Therapeutics Graduate Program, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., Tracz A; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA., Heidegger I; Department of Urology, Medical University Innsbruck, 6020, Innsbruck, Austria., Lagger S; Unit for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Trachtová K; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Central European Institute of Technology, Masaryk University, 60177, Brno, Czech Republic.; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, 1090, Vienna, Austria., Oberhuber M; Center for Biomarker Research in Medicine, 8010, Graz, Austria., Heitzer E; Institute of Human Genetics, Medical University of Graz, 8010, Graz, Austria., Aksoy O; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Department for Basic and Translational Oncology and Hematology, Division Molecular Oncology and Hematology, Karl Landsteiner University of Health Sciences, 3500, Krems, Austria., Neubauer HA; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Wingelhofer B; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Witzeneder N; Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria., Dillinger T; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Redl E; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Greiner G; Department of Laboratory Medicine, Medical University of Vienna, 1090, Vienna, Austria., D'Andrea D; Department of Urology, Medical University of Vienna, 1090, Vienna, Austria., Östman JR; Department of Molecular Sciences, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden., Tangermann S; Unit for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Hermanova I; Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), 20850, Derio, Spain., Schäfer G; Department of Pathology, Medical University Innsbruck, 6020, Innsbruck, Austria., Sternberg F; Institute of Physiology, Pathophysiology and Biophysics, University of Veterinary Medicine, 1210, Vienna, Austria., Pohl EE; Institute of Physiology, Pathophysiology and Biophysics, University of Veterinary Medicine, 1210, Vienna, Austria., Sternberg C; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Unit for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Biochemical Institute, University of Kiel, 24098, Kiel, Germany., Varady A; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Horvath J; Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria., Stoiber D; Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.; Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, 3500, Krems, Austria., Malcolm TI; Department of Pathology, University of Cambridge, Cambridge, CB20QQ, UK., Turner SD; Department of Pathology, University of Cambridge, Cambridge, CB20QQ, UK.; Institute of Medical Genetics and Genomics, Faculty of Medicine, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic., Parkes EE; Department of Oncology, University of Oxford, Oxford, OX37DQ, UK., Hantusch B; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria., Egger G; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria.; Ludwig Boltzmann Institute Applied Diagnostics, 1090, Vienna, Austria.; Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria., Rose-John S; Biochemical Institute, University of Kiel, 24098, Kiel, Germany., Poli V; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10126, Turin, Italy., Jain S; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT71NN, UK., Armstrong CWD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT71NN, UK., Hoermann G; MLL Munich Leukemia Laboratory, 81377, Munich, Germany., Goffin V; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, 75015, Paris, France., Aberger F; Department of Biosciences and Medical Biology, Cancer Cluster Salzburg, Paris-Lodron University of Salzburg, 5020, Salzburg, Austria., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Carracedo A; Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), 20850, Derio, Spain., McKinney C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT71NN, UK.; Almac Diagnostics, Craigavon, BT63 5QD, UK., Kennedy RD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT71NN, UK.; Almac Diagnostics, Craigavon, BT63 5QD, UK., Klocker H; Department of Urology, Medical University Innsbruck, 6020, Innsbruck, Austria., Speicher MR; Institute of Human Genetics, Medical University of Graz, 8010, Graz, Austria., Tang DG; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.; Experimental Therapeutics Graduate Program, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA., Moazzami AA; Department of Molecular Sciences, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden., Heery DM; School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK., Hacker M; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090, Vienna, Austria., Kenner L; Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Center for Biomarker Research in Medicine, 8010, Graz, Austria. lukas.kenner@meduniwien.ac.at.; Unit for Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210, Vienna, Austria. lukas.kenner@meduniwien.ac.at.; Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), Medical University of Vienna, 1090, Vienna, Austria. lukas.kenner@meduniwien.ac.at.
Source: Molecular cancer [Mol Cancer] 2023 Aug 12; Vol. 22 (1), pp. 133. Date of Electronic Publication: 2023 Aug 12.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1476-4598
DOI:10.1186/s12943-023-01825-8