Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.

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Title: Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
Authors: John L; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Poos AM; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Brobeil A; Department of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Schinke C; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Huhn S; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Prokoph N; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Lutz R; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Wagner B; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Zangari M; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Tirier SM; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany., Mallm JP; Single Cell Open Lab, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany., Schumacher S; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany., Vonficht D; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Solé-Boldo L; Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany., Quick S; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Steiger S; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany., Przybilla MJ; Division Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK., Bauer K; Single Cell Open Lab, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany., Baumann A; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hemmer S; Department of Orthopedic Surgery, Heidelberg University Hospital, Heidelberg, Germany., Rehnitz C; Department of Radiology, Heidelberg University Hospital, Heidelberg, Germany., Lückerath C; Department of Radiology, Heidelberg University Hospital, Heidelberg, Germany., Sachpekidis C; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mechtersheimer G; Department of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Haberkorn U; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany., Dimitrakopoulou-Strauss A; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany., Reichert P; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Barlogie B; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Müller-Tidow C; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany., Goldschmidt H; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany., Hillengass J; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Rasche L; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.; Mildred Scheel Early Career Center (MSNZ), University Hospital of Würzburg, Würzburg, Germany., Haas SF; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany., van Rhee F; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Rippe K; Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany., Raab MS; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sauer S; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Weinhold N; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. niels.weinhold@med.uni-heidelberg.de.; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. niels.weinhold@med.uni-heidelberg.de.; Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA. niels.weinhold@med.uni-heidelberg.de.
Source: Nature communications [Nat Commun] 2023 Aug 17; Vol. 14 (1), pp. 5011. Date of Electronic Publication: 2023 Aug 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-023-40584-4