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Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.

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Title: Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Authors: Graboski AL; Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Kowalewski ME; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Simpson JB; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Cao X; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA., Ha M; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Zhang J; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Walton WG; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Flaherty DP; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA., Redinbo MR; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: redinbo@unc.edu.
Source: Cell chemical biology [Cell Chem Biol] 2023 Nov 16; Vol. 30 (11), pp. 1402-1413.e7. Date of Electronic Publication: 2023 Aug 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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  Data: Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
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  Data: <searchLink fieldCode="AU" term="%22Graboski+AL%22">Graboski AL</searchLink>; Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kowalewski+ME%22">Kowalewski ME</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Simpson+JB%22">Simpson JB</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Ha+M%22">Ha M</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Walton+WG%22">Walton WG</searchLink>; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Flaherty+DP%22">Flaherty DP</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Redinbo+MR%22">Redinbo MR</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: redinbo@unc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101676030%22">Cell chemical biology</searchLink> [Cell Chem Biol] 2023 Nov 16; Vol. 30 (11), pp. 1402-1413.e7. <i>Date of Electronic Publication: </i>2023 Aug 25.
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