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The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates.

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Title: The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates.
Authors: Anwar IJ; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Berman DM; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.; Department of Surgery, University of Miami, Miami, FL 33136, USA., DeLaura I; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Gao Q; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Willman MA; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA., Miller A; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Gill A; ALS Therapy Development Institute, Cambridge, MA 02472, USA., Gill C; ALS Therapy Development Institute, Cambridge, MA 02472, USA., Perrin S; Eledon Pharmaceuticals, Irving, CA 92612, USA., Ricordi C; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.; Department of Surgery, University of Miami, Miami, FL 33136, USA.; Department of Microbiology and Immunology, University of Miami, Miami, FL 33136, USA.; Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA.; Department of Medicine, University of Miami, Miami, FL 33136, USA., Ruiz P; Department of Surgery, University of Miami, Miami, FL 33136, USA., Song M; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Ladowski JM; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Kirk AD; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA., Kenyon NS; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.; Department of Surgery, University of Miami, Miami, FL 33136, USA.; Department of Microbiology and Immunology, University of Miami, Miami, FL 33136, USA.; Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Aug 30; Vol. 15 (711), pp. eadf6376. Date of Electronic Publication: 2023 Aug 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates.
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  Data: <searchLink fieldCode="AU" term="%22Anwar+IJ%22">Anwar IJ</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Berman+DM%22">Berman DM</searchLink>; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.; Department of Surgery, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22DeLaura+I%22">DeLaura I</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Willman+MA%22">Willman MA</searchLink>; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Miller+A%22">Miller A</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Gill+A%22">Gill A</searchLink>; ALS Therapy Development Institute, Cambridge, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Gill+C%22">Gill C</searchLink>; ALS Therapy Development Institute, Cambridge, MA 02472, USA.<br /><searchLink fieldCode="AU" term="%22Perrin+S%22">Perrin S</searchLink>; Eledon Pharmaceuticals, Irving, CA 92612, USA.<br /><searchLink fieldCode="AU" term="%22Ricordi+C%22">Ricordi C</searchLink>; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.; Department of Surgery, University of Miami, Miami, FL 33136, USA.; Department of Microbiology and Immunology, University of Miami, Miami, FL 33136, USA.; Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA.; Department of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+P%22">Ruiz P</searchLink>; Department of Surgery, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Song+M%22">Song M</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Ladowski+JM%22">Ladowski JM</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Kirk+AD%22">Kirk AD</searchLink>; Duke Transplant Center, Department of Surgery, Duke University School of Medicine; Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Kenyon+NS%22">Kenyon NS</searchLink>; Diabetes Research Institute, University of Miami, Miami, FL 33136, USA.; Department of Surgery, University of Miami, Miami, FL 33136, USA.; Department of Microbiology and Immunology, University of Miami, Miami, FL 33136, USA.; Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2023 Aug 30; Vol. 15 (711), pp. eadf6376. <i>Date of Electronic Publication: </i>2023 Aug 30.
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