Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
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| Title: | Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity. |
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| Authors: | Syed A; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Filandr F; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada., Patterson-Fortin J; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Bacolla A; Department of Molecular and Cellular Oncology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ravindranathan R; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Zhou J; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., McDonald DT; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Albuhluli ME; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Verway-Cohen A; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Newman JA; Center for Medicines Discovery, University of Oxford, OX1 3QU, UK., Tsai MS; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Jones DE; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Schriemer DC; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada., D'Andrea AD; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Tainer JA; Department of Molecular and Cellular Oncology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2023 Oct 13; Vol. 51 (18), pp. 9920-9937. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkad727 |
