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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.

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Title: Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Authors: Syed A; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Filandr F; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada., Patterson-Fortin J; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Bacolla A; Department of Molecular and Cellular Oncology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ravindranathan R; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Zhou J; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., McDonald DT; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Albuhluli ME; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Verway-Cohen A; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Newman JA; Center for Medicines Discovery, University of Oxford, OX1 3QU, UK., Tsai MS; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Jones DE; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Schriemer DC; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada., D'Andrea AD; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Tainer JA; Department of Molecular and Cellular Oncology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Source: Nucleic acids research [Nucleic Acids Res] 2023 Oct 13; Vol. 51 (18), pp. 9920-9937.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
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  Data: <searchLink fieldCode="AU" term="%22Syed+A%22">Syed A</searchLink>; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Filandr+F%22">Filandr F</searchLink>; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.<br /><searchLink fieldCode="AU" term="%22Patterson-Fortin+J%22">Patterson-Fortin J</searchLink>; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Bacolla+A%22">Bacolla A</searchLink>; Department of Molecular and Cellular Oncology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ravindranathan+R%22">Ravindranathan R</searchLink>; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+DT%22">McDonald DT</searchLink>; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Albuhluli+ME%22">Albuhluli ME</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.<br /><searchLink fieldCode="AU" term="%22Verway-Cohen+A%22">Verway-Cohen A</searchLink>; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Newman+JA%22">Newman JA</searchLink>; Center for Medicines Discovery, University of Oxford, OX1 3QU, UK.<br /><searchLink fieldCode="AU" term="%22Tsai+MS%22">Tsai MS</searchLink>; Biological and System Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DE%22">Jones DE</searchLink>; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.<br /><searchLink fieldCode="AU" term="%22Schriemer+DC%22">Schriemer DC</searchLink>; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada.<br /><searchLink fieldCode="AU" term="%22D'Andrea+AD%22">D'Andrea AD</searchLink>; Division of Radiation and Genome Instability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.; Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Tainer+JA%22">Tainer JA</searchLink>; Department of Molecular and Cellular Oncology, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
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              Text: 2023 Oct 13
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