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A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.

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Title: A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.
Authors: Antal CE; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA., Oh TG; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA., Aigner S; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Luo EC; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Yee BA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Campos T; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Tiriac H; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA., Rothamel KL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Cheng Z; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA., Jiao H; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA., Wang A; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA., Hah N; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Lenkiewicz E; Mayo Clinic in Arizona, Scottsdale, AZ, 85259, USA., Lumibao JC; Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Truitt ML; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Estepa G; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Banayo E; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Bashi S; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Esparza E; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA., Munoz RM; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Diedrich JK; Mass Spectrometry Core for Proteomics and Metabolomics, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Sodir NM; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Genentech, Department of Translational Oncology, 1 DNA Way, South San Francisco, CA, 94080, USA., Mueller JR; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Fraser CR; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA.; Scottsdale Pathology Associates, Scottsdale, AZ, 85260, USA., Borazanci E; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA., Propper D; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, USA., Von Hoff DD; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA., Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead Hospital, Westmead, NSW, 2145, Australia., Yu RT; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Atkins AR; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Han H; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Lowy AM; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA., Barrett MT; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Engle DD; Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Evan GI; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, 92037, USA., Downes M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. downes@salk.edu., Evans RM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. evans@salk.edu.
Source: Nature communications [Nat Commun] 2023 Sep 06; Vol. 14 (1), pp. 5195. Date of Electronic Publication: 2023 Sep 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-023-40798-6