Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice.

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Title: Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice.
Authors: Liu Y; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Reiken S; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Dridi H; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Yuan Q; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Mohammad KS; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Present address: College of Medicine, Alfaisal University, Box 50927, Riyadh 1153, Kingdom of Saudi Arabia., Trivedi T; Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Miotto MC; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Wedderburn-Pugh K; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Sittenfeld L; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Kerley Y; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Meyer JA; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Peters JS; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Persohn SC; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Bedwell AA; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Figueiredo LL; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Suresh S; Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., She Y; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Soni RK; Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA., Territo PR; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Marks AR; Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Guise TA; Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Sep 27; Vol. 15 (715), pp. eadf8977. Date of Electronic Publication: 2023 Sep 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adf8977