Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.

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Title: Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
Authors: Yuan Y; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Lopez-Santiago L; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Denomme N; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Chen C; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., O'Malley HA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Hodges SL; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Ji S; Stoke Therapeutics, Inc., Bedford, MA 01730, USA., Han Z; Stoke Therapeutics, Inc., Bedford, MA 01730, USA., Christiansen A; Stoke Therapeutics, Inc., Bedford, MA 01730, USA., Isom LL; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Source: Brain : a journal of neurology [Brain] 2024 Apr 04; Vol. 147 (4), pp. 1231-1246.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2156
DOI:10.1093/brain/awad349