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Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.

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Title: Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
Authors: Ekoka Mbassi D; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany., Mombo-Ngoma G; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Held J; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany., Okwu DG; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ndzebe-Ndoumba W; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kalkman LC; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Ekoka Mbassi FA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany., Pessanha de Carvalho L; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Inoue J; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Akinosho MA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Dimessa Mbadinga LB; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Yovo EK; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Mordmüller B; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands., Kremsner PG; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany., Adegnika AA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany; Department of Parasitology, Leiden University Medical Centre (LUMC), 2333 ZA, Leiden, the Netherlands; Fondation pour la Recherche Scientifique, 72 BP45, Cotonou, Benin., Ramharter M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany., Zoleko-Manego R; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Electronic address: rella.zoleko-manego@bnitm.de.
Source: EBioMedicine [EBioMedicine] 2023 Nov; Vol. 97, pp. 104814. Date of Electronic Publication: 2023 Oct 13.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3964
DOI:10.1016/j.ebiom.2023.104814