Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.

Saved in:
Bibliographic Details
Title: Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
Authors: Ekoka Mbassi D; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany., Mombo-Ngoma G; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Held J; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany., Okwu DG; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ndzebe-Ndoumba W; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kalkman LC; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Ekoka Mbassi FA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany., Pessanha de Carvalho L; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Inoue J; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Akinosho MA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Dimessa Mbadinga LB; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Yovo EK; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Mordmüller B; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands., Kremsner PG; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany., Adegnika AA; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany; Department of Parasitology, Leiden University Medical Centre (LUMC), 2333 ZA, Leiden, the Netherlands; Fondation pour la Recherche Scientifique, 72 BP45, Cotonou, Benin., Ramharter M; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany., Zoleko-Manego R; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Electronic address: rella.zoleko-manego@bnitm.de.
Source: EBioMedicine [EBioMedicine] 2023 Nov; Vol. 97, pp. 104814. Date of Electronic Publication: 2023 Oct 13.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 37839134
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Ekoka+Mbassi+D%22">Ekoka Mbassi D</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany.<br /><searchLink fieldCode="AU" term="%22Mombo-Ngoma+G%22">Mombo-Ngoma G</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Held+J%22">Held J</searchLink>; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Okwu+DG%22">Okwu DG</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ndzebe-Ndoumba+W%22">Ndzebe-Ndoumba W</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kalkman+LC%22">Kalkman LC</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.<br /><searchLink fieldCode="AU" term="%22Ekoka+Mbassi+FA%22">Ekoka Mbassi FA</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany.<br /><searchLink fieldCode="AU" term="%22Pessanha+de+Carvalho+L%22">Pessanha de Carvalho L</searchLink>; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Inoue+J%22">Inoue J</searchLink>; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Akinosho+MA%22">Akinosho MA</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.<br /><searchLink fieldCode="AU" term="%22Dimessa+Mbadinga+LB%22">Dimessa Mbadinga LB</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.<br /><searchLink fieldCode="AU" term="%22Yovo+EK%22">Yovo EK</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.<br /><searchLink fieldCode="AU" term="%22Mordmüller+B%22">Mordmüller B</searchLink>; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kremsner+PG%22">Kremsner PG</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Adegnika+AA%22">Adegnika AA</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany; Department of Parasitology, Leiden University Medical Centre (LUMC), 2333 ZA, Leiden, the Netherlands; Fondation pour la Recherche Scientifique, 72 BP45, Cotonou, Benin.<br /><searchLink fieldCode="AU" term="%22Ramharter+M%22">Ramharter M</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany.<br /><searchLink fieldCode="AU" term="%22Zoleko-Manego+R%22">Zoleko-Manego R</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Centre for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Germany; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Electronic address: rella.zoleko-manego@bnitm.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2023 Nov; Vol. 97, pp. 104814. <i>Date of Electronic Publication: </i>2023 Oct 13.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101647039 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3964 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523964%22">23523964 </searchLink><i>NLM ISO Abbreviation: </i>EBioMedicine <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=37839134
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ebiom.2023.104814
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 104814
    Titles:
      – TitleFull: Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ekoka Mbassi D
      – PersonEntity:
          Name:
            NameFull: Mombo-Ngoma G
      – PersonEntity:
          Name:
            NameFull: Held J
      – PersonEntity:
          Name:
            NameFull: Okwu DG
      – PersonEntity:
          Name:
            NameFull: Ndzebe-Ndoumba W
      – PersonEntity:
          Name:
            NameFull: Kalkman LC
      – PersonEntity:
          Name:
            NameFull: Ekoka Mbassi FA
      – PersonEntity:
          Name:
            NameFull: Pessanha de Carvalho L
      – PersonEntity:
          Name:
            NameFull: Inoue J
      – PersonEntity:
          Name:
            NameFull: Akinosho MA
      – PersonEntity:
          Name:
            NameFull: Dimessa Mbadinga LB
      – PersonEntity:
          Name:
            NameFull: Yovo EK
      – PersonEntity:
          Name:
            NameFull: Mordmüller B
      – PersonEntity:
          Name:
            NameFull: Kremsner PG
      – PersonEntity:
          Name:
            NameFull: Adegnika AA
      – PersonEntity:
          Name:
            NameFull: Ramharter M
      – PersonEntity:
          Name:
            NameFull: Zoleko-Manego R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2023 Nov
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-electronic
              Value: 2352-3964
          Numbering:
            – Type: volume
              Value: 97
          Titles:
            – TitleFull: EBioMedicine
              Type: main
ResultId 1