Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease.
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| Title: | Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease. |
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| Authors: | Sastre D; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr., R271/217, Stanford, CA, 94305, USA., Zafar F; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr., R271/217, Stanford, CA, 94305, USA., Torres CAM; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr., R271/217, Stanford, CA, 94305, USA., Piper D; Department of Biological Sciences, San Jose State University, San Jose, CA, 95192, USA., Kirik D; Department of Experimental Medical Science, Lund University, Lund, Sweden., Sanders LH; Departments of Neurology and Pathology, Duke Center for Neurodegeneration and Neurotherapeutics, Duke University Medical Center, Durham, NC, 27710, USA., Qi LS; Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA., Schüle B; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr., R271/217, Stanford, CA, 94305, USA. bschuele@stanford.edu.; Biosciences Division, SRI International, Menlo Park, CA, 94025, USA. bschuele@stanford.edu. |
| Source: | Scientific reports [Sci Rep] 2023 Oct 18; Vol. 13 (1), pp. 17796. Date of Electronic Publication: 2023 Oct 18. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-023-45078-3 |
