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First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.

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Title: First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.
Authors: Mahmood SU; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Lozano Gonzalez M; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Tummalapalli S; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Eberhard J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Ly J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Hoffman CS; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Kelly MP; Department of Anatomy & Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, United States., Gordon J; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Colussi D; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Childers W; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Rotella DP; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14597-14608. Date of Electronic Publication: 2023 Oct 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mahmood+SU%22">Mahmood SU</searchLink>; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.<br /><searchLink fieldCode="AU" term="%22Lozano+Gonzalez+M%22">Lozano Gonzalez M</searchLink>; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.<br /><searchLink fieldCode="AU" term="%22Tummalapalli+S%22">Tummalapalli S</searchLink>; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.<br /><searchLink fieldCode="AU" term="%22Eberhard+J%22">Eberhard J</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Ly+J%22">Ly J</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Hoffman+CS%22">Hoffman CS</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+MP%22">Kelly MP</searchLink>; Department of Anatomy & Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Gordon+J%22">Gordon J</searchLink>; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Colussi+D%22">Colussi D</searchLink>; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Childers+W%22">Childers W</searchLink>; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Rotella+DP%22">Rotella DP</searchLink>; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14597-14608. <i>Date of Electronic Publication: </i>2023 Oct 20.
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              Text: 2023 Nov 09
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